What are the Causes and mechanism of celiac disease development?
Celiac disease is an autoimmune disorder that damages the small intestine when gluten is ingested. Gluten is a protein found in wheat, barley, and rye. People with celiac disease have an abnormal immune response to gluten, which triggers an inflammatory reaction in the small intestine. This inflammation can damage the villi, which are small finger-like projections that line the small intestine. Villi are responsible for absorbing nutrients from food, so when they are damaged, people with celiac disease may not absorb enough nutrients from their diet. Causes and mechanism of celiac disease development The exact cause of celiac disease is not fully understood, but it is thought to be caused by a combination of genetic and environmental factors. The genetic risk factors for celiac disease include having certain human leukocyte antigen (HLA) genes. HLA genes are responsible for presenting antigens to the immune system. In people with celiac disease, the immune system mistakenly attac...