What is the average weight loss with Tirzepatide over 12 weeks?

 Tirzepatide is a medication that is FDA-approved for the treatment of type 2 diabetes. It works as a dual GLP-1 agonist and GIP agonist to maximize similar benefits that are seen with GLP-1 medications such as semaglutide

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. During clinical trials, participants lost up to 20.9% of their starting weight with 15-mg doses of tirzepatide

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.A study published on NCBI showed that at week 12, body weight decreased in each tirzepatide treatment group from baseline. The reductions ranged from −0.5 kg in the lowest dose group to −7.8 kg in the highest dose group

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. Another study showed that tirzepatide achieved up to 15.7% weight loss in adults with obesity or overweight and type 2 diabetes

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.In a systematic review and meta-analysis of all currently available randomized controlled trials (RCTs) of tirzepatide in individuals with T2DM and obesity, a significant reduction in body weight in the tirzepatide group versus the placebo group by -9.81 kg was observed

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.It is important to note that the weight loss results may vary depending on the individual, their starting weight, and other factors.If you are considering tirzepatide for weight loss, it is important to discuss the potential benefits and risks with your healthcare provider.

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nejm

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wiley

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lilly

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nih