Wednesday, June 28, 2023

Is it true low magnesium may increase the risk of sudden death? Is there any thorough study to suggest that?

 Yes, low magnesium levels have been associated with an increased risk of sudden death, particularly sudden cardiac death

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 Magnesium is essential for maintaining normal cellular physiology and metabolism, and it plays a critical role in regulating ion channels and energy generation, intracardiac conduction, and myocardial contraction
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 Magnesium deficiency sensitizes the myocardium to toxic effects and can cause cardiac arrhythmias and coronary artery vasospasm
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 However, despite the substantial number of studies linking magnesium deficiency with sudden death, no prospective studies have yet been conducted
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One study, the Atherosclerosis Risk in Communities (ARIC) Study, assessed risk factors and levels of serum magnesium in a cohort of 45-64-year-olds in 1987-1989. After an average of 12 years of follow-up, the study observed 264 cases of sudden cardiac death, as determined by physician review of all suspected cases. Individuals in the highest quartile of serum magnesium were at significantly lower risk of sudden cardiac death in all models. This association persisted after adjustment for potential confounding variables, with an almost 40% reduced risk of sudden cardiac death in quartile 4 vs. 1 of serum magnesium observed in the fully adjusted model
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In conclusion, low magnesium levels have been associated with an increased risk of sudden death, particularly sudden cardiac death. Magnesium is essential for maintaining normal cellular physiology and metabolism, and it plays a critical role in regulating ion channels and energy generation, intracardiac conduction, and myocardial contraction. However, more research is needed to determine the effectiveness of magnesium supplementation in reducing the risk of sudden death
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