Saturday, July 22, 2023

what are the benefits of tirzepatide for type 2 diabetes patients?

 Tirzepatide is a medication that is FDA approved for the treatment of type 2 diabetes mellitus

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 It is a dual GIP and GLP-1 receptor agonist, which means that it works by stimulating both the GIP and GLP-1 receptors in the body
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Tirzepatide has been shown to be effective in reducing body weight in overweight and obese patients with type 2 diabetes. In a global phase 3 trial, patients with obesity and type 2 diabetes or with overweight and type 2 diabetes lost an estimated 34.4 pounds (15.7%) of body weight with 10 mg and 15 mg of tirzepatide
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 The SURMOUNT-2 study found that individuals with type 2 diabetes and obesity lost an average of 15% of their body weight after 72 weeks of treatment with tirzepatide
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In addition to weight loss, tirzepatide has been shown to be effective in improving blood sugar control in adults with type 2 diabetes. In clinical trials, all doses of tirzepatide demonstrated superiority in reducing A1C and body weight from baseline versus placebo or active comparators
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 Tirzepatide works to stimulate first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose-dependent manner
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 It also delays gastric emptying, lowers fasting and postprandial glucose levels, and reduces food intake
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Tirzepatide is administered as a once-a-week subcutaneous injectable
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 It is currently implemented as a second-line diabetes medication, similar to GLP-1 medications
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 Tirzepatide is also being studied for its potential use in treating obesity
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In summary, tirzepatide has been shown to be effective in reducing body weight and improving blood sugar control in adults with type 2 diabetes. It works by stimulating both the GIP and GLP-1 receptors in the body, which results in reduced glucagon levels, delayed gastric emptying, lower glucose levels, and reduced food intake. Tirzepatide is administered as a once-a-week subcutaneous injectable.

Citations:
[1] https://jamanetwork.com/journals/jama/fullarticle/2788799
[2] https://pubmed.ncbi.nlm.nih.gov/35929488/
[3] https://www.fiercepharma.com/pharma/lilly-s-tirzepatide-doesn-t-necessarily-top-diabetes-rivals-jardiance-and-ozempic-icer-says
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231274/
[5] https://diabetesjournals.org/clinical/article/41/2/258/148021/Efficacy-and-Safety-of-Tirzepatide-in-Adults-With
[6] https://www.healthline.com/health/tirzepatide-vs-semaglutide
[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268041/
[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987449/
[9] https://www.frontiersin.org/articles/10.3389/fphar.2022.1016639/full
[10] https://www.nature.com/articles/s41591-023-02344-1
[11] https://www.fda.gov/news-events/press-announcements/fda-approves-novel-dual-targeted-treatment-type-2-diabetes
[12] https://www.joincalibrate.com/resources/tirzepatide-vs-semaglutide
[13] https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-achieved-157-weight-loss-adults-obesity-or
[14] https://diabetes.org/newsroom/press-releases/2023/surmount-2-study-finds-individuals-type%202-diabetes-obesity-lost-average-15-percent-body-weight-taking-tirzepatide
[15] https://www.nejm.org/doi/full/10.1056/NEJMoa2107519

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