Friday, July 14, 2023

what happens to bone cells during radiation therapy?

 During radiation therapy, several effects can occur in bone cells. Here are some key points from the search results:


- Radiation therapy can cause damage to normal, non-tumor bone tissue, increasing the risk of fractures among cancer patients[1].

- Specific bone complications of radiation therapy include osteopenia (reduced bone density), growth arrest, fractures, and malignancy[2].

- Radiation can lead to insufficiency fractures, which commonly affect bones under the most physiological stress and with a higher ratio of trabecular to cortical bone[2].

- High doses of radiation can cause bone destruction, increased bone resorption by osteoclasts, and reduced bone formation by osteoblasts[3].

- The effects of radiation on bone are dose-dependent, and some complications, such as osteopenia, can be reversible[2].

- The relationship between radiation and osteoclast activity (bone resorption) is not well-studied, and more research is needed to understand the specific mechanisms[4].

- Vascular changes induced by radiation are also important and can contribute to fractures[5].

- Low doses of radiation used in chronic degenerative and inflammatory diseases may have a positive impact on bone homeostasis[3].

- Future research is necessary to elucidate the influence of different bone cells on the overall effects of radiation on bone[6].


It's important to note that the effects of radiation on bone cells can vary depending on factors such as the dose and duration of radiation therapy, as well as individual characteristics. If you have concerns about the effects of radiation therapy on your bone cells, it's best to discuss them with your doctor, who can provide personalized information and guidance.


Citations:

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401480/

[2] https://pubmed.ncbi.nlm.nih.gov/24057133/

[3] https://pubmed.ncbi.nlm.nih.gov/32887421/

[4] https://tigerprints.clemson.edu/cgi/viewcontent.cgi?article=1181&context=all_dissertations

[5] https://pubs.rsna.org/doi/10.1148/59.5.744

[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504528/

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