Friday, July 14, 2023

how does radiation therapy affect bone cells and DNA?

 Radiation therapy is a common treatment for cancer that uses high-energy rays or particles to kill cancer cells. However, it can also affect normal cells, including bone cells and DNA.

Radiation can directly affect DNA structure by inducing DNA breaks, particularly double-strand breaks (DSBs). It can also generate reactive oxygen species (ROS) that oxidize proteins and lipids and induce several damages to DNA, such as the generation of abasic sites and single-strand breaks (SSBs) 
 These damages can lead to cell death or prevent the DNA from replicating correctly
Radiation can also lead to bone loss and increase the risk of osteoporosis and fractures. High doses of radiation can cause bone destruction with increased bone resorption by osteoclasts and reduced bone formation by osteoblasts
 Molecular signals from chemotherapy-induced senescent cells can disrupt a process known as bone remodeling, leading to bone loss in mice receiving chemotherapy
It's important to note that not everyone who receives radiation therapy will experience bone loss or DNA damage. The severity of the effects depends on the dose and duration of radiation therapy, as well as individual factors such as age and overall health
If you're concerned about the effects of radiation therapy on your bone cells and DNA, it's always best to talk to your doctor. They can provide more information about your individual risk and recommend any necessary screening or monitoring.


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