Syphilis develops in four stages, and each stage has different signs and symptoms 3 1 2 4 5 6 . The symptoms of syphilis can vary with each stage, and they might not always happen in the same order for everyone. Here are the symptoms of syphilis in each stage: Primary stage: During the primary stage of syphilis, one or more sores (chancres) form at the site where the bacteria entered the body. This often occurs within 3 weeks of exposure but can range from 10 to 90 days. A person is highly contagious during the primary stage and can easily pass the infection to others. The sore is usually painless, and it can be found in, on, or around the penis, vagina, anus, rectum, and lips or in the mouth 1 2 3 4 5 6 . Secondary stage: The secondary stage of syphilis usually occurs several weeks after the primary stage. During this stage, a rash may appear on the palms of your hands, soles of your feet, or other parts of your body. The rash often forms over the body, often on the palms ...
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