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what are the causes of hemophilia?

  Hemophilia is a rare, hereditary bleeding disorder in which the blood does not clot properly. It is caused by a mutation or change in one of the genes that provides instructions for making the clotting factor proteins needed to form a blood clot 2 .   Hemophilia occurs in two sub-types: hemophilia A and hemophilia B. In hemophilia A, there is a lack or total absence of coagulation factor VIII 1 . symptoms The most common symptom of hemophilia is bleeding, particularly into the joints and muscles. When a person with hemophilia is injured, they do not bleed faster than a person without hemophilia, but it takes longer for bleeding to stop. Bleeding may start again several days after an injury or surgery. Small cuts or surface bruises usually are not a problem, but deeper injuries may result in bleeding episodes that can lead to permanent disability unless they are treated promptly. Other symptoms of hemophilia include easy bruising, prolonged nosebleeds, or vomiting of blood 4 ...